ERK (pan ERK) Mouse, Unlabeled, Clone: 16, BD

Mouse Monoclonal Antibody

Produktkode	Brand	Quantity
15805279	BD Biosciences 610123	50 μg
15815279	BD Biosciences 610124	150 μg

Beskrivelse

The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) are activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK1 may be observable migrating at 44kDa and ERK2 at 42kDa in addition to a 54kDa ERK and a MAP kinase in the 90kDa range.

Host Species: Mouse
Clone: 16
Isotype: IgG2a
Species Reactivity: Mouse
Immunogen: Rat ERK2 aa. 219-358
Formula Weight [Chemical]: 42-85kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Tekniske data

• Antigen: ERK (pan ERK)
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG2a
• Purification Method: Affinity Purified
• Description: Extracellular signal Regulated Kinases

• Clone: 16
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Canine, Chicken, Frog, Human, Mouse, Rat
• Immunogen: Rat ERK2 aa. 219-358
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.