Bcl-X set Mouse, Unlabeled, Clone: 2H12, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 551020

Product Code. 15866478

Description

Members of the Bcl-2 family play a major role in regulating the response of cells to a wide variety of apoptotic signals. Some Bcl-2 family members like Bcl-2, block apoptosis, whereas others promote apoptosis and inhibit Bcl-2 activity. Bcl-x is a Bcl-2 homologue that has two isoforms, resulting from alternative splicing. Bcl-xL (long) is a 241 amino acid protein (25-29 kDa) that is 47% homologous to Bcl-2 on the amino acid level. Bcl-xS (short) is a 178 amino acid protein (∼ 19.5 kDa) lacking a 63 amino acid domain that is well conserved among members of the Bcl-2 protein family. Bcl-xL blocks cell death, whereas Bcl-xS inhibits Bcl-2 and promotes cell death.

Specifications

• Antigen: Bcl-X set
• Classification: Monoclonal
• Conjugate: Unconjugated
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: Western Blot
• Clone: 2H12
• Host Species: Mouse
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Human, Mouse
• Isotype: IgG2a

For Research Use Only.