Invitrogen™ Ankyrin B Monoclonal Antibody (K52014_1E12), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA555908

Product Code. 30212853

Description

Sequence of this protein is as follows: DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY LKGGIDINTC NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA LHIASLAGQA EVVKVLVKEG ANINAQSQNG FTPLYMAAQE NHIDVVKYLL ENGANQSTAT EDGFTPLAVA LQQGHNQAVA ILLENDTKGK VRLPALHIAA RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL TPLHCAARSG

This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.

Specifications

• Antigen: Ankyrin B
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
• Gene Accession No.: Q01484
• Gene Symbols: ANK2
• Immunogen: Recombinant human ANK2 (immunogen range is 11-310).
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: K52014_1E12
• Conjugate: Unconjugated
• Gene: ANK2
• Gene Alias: AI835472; Ank2; ANK-2; Ank3; AnkB; ankyrin 2, brain; ankyrin 2, neuronal; ankyrin 3, epithelial; ankyrin B; ankyrin, brain; ankyrin-2; ankyrin-2, nonerythrocytic; ankyrin-B; AW491075; Brain ankyrin; brank-2; LQT4; Non-erythroid ankyrin
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 287
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid