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Thermo Scientific™ ActivX™ Fluorophosphonate Probes

Tagged phosphonate probes to assay serine hydrolase active sites using fluorescence, biotin-affinity purification or detection, or mass spectrometry.

Brand:  Thermo Scientific™ 88317

Code : PN

Additional Details : Weight : 0.01000kg

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Product Code. 11844624

  • £347.21 / Each

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ActivX FP Probes feature a reactive fluorophosphonate group that specifically and covalently labels the active-site serine of enzymatically active serine hydrolases. These probes are available with a desthiobiotin (biotin analog) tag for selective enrichment, TAMRA fluorophore for detection or a reactive- azido group (Staudinger reagents) that facilitates multiplex labeling when used with phosphine- or alkyne-derivatized tags. These probes can be used to assess activity or screen small molecule inhibitors against enzymes derived from cell lysates, subcellular fractions, tissues and recombinant proteins.


  • Specific – labels the reactive site of active serine hydrolases

  • Compatible – tags available for capture, detection and Staudinger conjugation

  • Flexible – use for in vitro or intracellular enzyme labeling

Recommended for:

Determine serine hydrolase enzyme activity in cells and lysates; Mapping the active-site serine of functionally diverse serine hydrolase family members (e.g. proteases, lipases, esterases); Screen for small molecule binding affinities and active-site inhibition; Profile serine hydrolases using fluorescent, Western blot or mass spectrometry workflows



ActivX Desthiobiotin-FP Serine Hydrolase Probe
Desthiobiotin-fluorophosphonate, MW 464
100 labeling reactions or 10 pull-down assays