AATF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16896563	Proteintech 10282-1-AP-20UL	20 μL
16886563	Proteintech 10282-1-AP-150UL	150 μL

Description

AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the beta-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer′s disease (AD), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.

Specifications

• Antigen: AATF
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q9JKX4, Q9NY61, Q9QYW0
• Gene ID (Entrez): 114512, 26574, 56321
• Immunogen: AATF Fusion Protein Ag0195
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: AATF

• Concentration: 0.39 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube
• Gene Symbols: AATF
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody