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  5. Tocris Bioscience™ A 83-01

Tocris Bioscience™ A 83-01
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Product Code. 18084932
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
Product Code. Quantity unitSize
18084932 10 mg 10mg
18025492 50 mg 50mg
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Product Code. 18084932

Brand: Tocris Bioscience™ 2939/10

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204.80 GBP valid until 2026-03-31
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This item is not returnable. View return policy

Description

Selective inhibitor of TGF-βRI, ALK4 and ALK7

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat. No. 1614). A 83-01 inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. Also promotes neural differentiation of hPSCs as part of a chemical cocktail.

For more information about how A 83-01 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 909910-43-6
Molecular Formula C25H19N5S

Specifications

Quantity 10 mg
Formula Weight 421.52
Purity >98%
Molecular Weight (g/mol) 421.522
Chemical Name or Material A 83-01
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