2-Amino-4,6-dichloropyrimidine, 98%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11443734	Thermo Scientific Alfa Aesar A11330.06	5 g
11453734	Thermo Scientific Alfa Aesar A11330.14	25 g
11399689	Thermo Scientific Alfa Aesar A11330.22	100 g

Description

Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.

Solubility
Insoluble in water, soluble in acetone, two monomer (VCM) and thermal toluene.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Chemical Identifiers

• CAS: 56-05-3
• Molecular Weight (g/mol): 163.989
• InChI Key: JPZOAVGMSDSWSW-UHFFFAOYSA-N
• PubChem CID: 65522
• SMILES: C1=C(N=C(N=C1Cl)N)Cl

• Molecular Formula: C4H3Cl2N3
• MDL Number: MFCD00006090
• Synonym: 2-amino-4,6-dichloropyrimidine, 4,6-dichloro-2-pyrimidinamine, 2-pyrimidinamine, 4,6-dichloro, 4,6-dichloropyrimidin-2-ylamine, ccris 7460, 4,6-dichloro-pyrimidin-2-ylamine, pyrimidine, 2-amino-4,6-dichloro, 2-amino-4,6-dichloro pyrimidine, 4,6-dichloropyrimidine-2-ylamine, zlchem 351
• IUPAC Name: 4,6-dichloropyrimidin-2-amine

Specifications

• CAS: 56-05-3
• Molecular Formula: C4H3Cl2N3
• Beilstein: 118454
• Solubility Information: Insoluble in water,soluble in acetone,two monomer (VCM) and thermal toluene.
• SMILES: C1=C(N=C(N=C1Cl)N)Cl
• Molecular Weight (g/mol): 163.989
• Formula Weight: 164
• Chemical Name or Material: 2-Amino-4,6-dichloropyrimidine

• Melting Point: 218°C to 222°C
• MDL Number: MFCD00006090
• Synonym: 2-amino-4,6-dichloropyrimidine, 4,6-dichloro-2-pyrimidinamine, 2-pyrimidinamine, 4,6-dichloro, 4,6-dichloropyrimidin-2-ylamine, ccris 7460, 4,6-dichloro-pyrimidin-2-ylamine, pyrimidine, 2-amino-4,6-dichloro, 2-amino-4,6-dichloro pyrimidine, 4,6-dichloropyrimidine-2-ylamine, zlchem 351
• InChI Key: JPZOAVGMSDSWSW-UHFFFAOYSA-N
• IUPAC Name: 4,6-dichloropyrimidin-2-amine
• PubChem CID: 65522
• Percent Purity: 98%

Safety and Handling

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

H315-H319-H335

missing translation for 'einecsNumber' : 200-253-9

missing translation for 'rtecsNumber' : UV6260485

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

RUO – Research Use Only