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DiscoverX PathHunter™ eXpress NMBR CHO-K1 β-Arrestin GPCR Assay

Product Code. 17334019
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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Product Code. Quantity unitSize
17334019 1,000 dp (10 x 96-well) 1 set
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Product Code. 17334019 Supplier DiscoverX Supplier No. 930925E2CP2L

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Description

The PathHunter™ eXpress NMBR CHO-K1 β-Arrestin GPCR Assay measures NMBR (GPCR) activity via recruitment of β-Arrestin2. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ NMBR β-Arrestin eXpress Kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. neuromedin B) based activation of NMBR GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cells overexpress PK-tagged NMBR and EA-tagged β-Arrestin 2. Activation of NMBR stimulates the recruitment of β-Arrestin 2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry β-Arrestin-2 recruitment
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist Neuromedin B (porcine)
Quantity 1,000 dp (10 x 96-well)
Target Entry NMBR
Cell Line CHO-K1
Target NMBR
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