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DiscoverX PathHunter™ eXpress GPR50 CHO-K1 β-Arrestin Orphan GPCR Assay

Product Code. 17373589
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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Product Code. Quantity unitSize
17373589 1,000 dp (10 x 96-well) 1 set
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Product Code. 17373589 Supplier DiscoverX Supplier No. 930648E2CP1L

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Description

The PathHunter™ eXpress GPR50 CHO-K1 β-Arrestin Orphan GPCR Assay measures GPR50 (GPCR) activity via recruitment of β-Arrestin2. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ GPR50 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR50 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cells overexpress PK-tagged GPR50 and EA-tagged β-Arrestin 2. Activation of GPR50 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Orphan receptor with unknown ligand.

Specifications

Assay Entry GPCR
For Use With (Application) Assay-Ready eXpress Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry GPR50
Cell Line CHO-K1
Target GPR50
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