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DiscoverX PathHunter™ eXpress CCR7 HEK 293 β-Arrestin GPCR Assay

Product Code. 17382709
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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Product Code. Quantity unitSize
17382709 1,000 dp (10 x 96-well) 1 set
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Product Code. 17382709 Supplier DiscoverX Supplier No. 930195E1CP0L

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Description

The PathHunter™ eXpress CCR7 HEK 293 β-Arrestin GPCR Assay measures CCR7 (GPCR) activity via recruitment of β-Arrestin2. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ CCR7 β-Arrestin eXpress Kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL19/MIP-3β) based activation of CCR7 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cells overexpress PK-tagged CCR7 and EA-tagged β-Arrestin 2. Activation of CCR7 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

For Use With (Application) Assay-Ready eXpress Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry CCR7
Cell Line 293H
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