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DiscoverX PathHunter™ eXpress AVPR1B Activated GPCR Internalization Assay

Product Code. 17333719
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Quantity:
200 dp (2 x 96-well)
Unit Size:
1 set
Product Code. Quantity unitSize
17333719 200 dp (2 x 96-well) 1 set
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Product Code. 17333719

Brand: DiscoverX 930722E3CP5M

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress AVPR1B Activated GPCR Internalization Assay measures AVPR1B (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ AVPR1B Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. vasopressin) based internalization of AVPR1B via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged AVPR1B. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting AVPR1B-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry GPCR
For Use With (Application) Assay-Ready eXpress Kits
Quantity 200 dp (2 x 96-well)
Target Entry AVPR1B
Target AVPR1B
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