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  6. 17-(Allylamino)-17-demethoxygeldanamycin, 99%

17-(Allylamino)-17-demethoxygeldanamycin, 99%

Product Code. 15428539
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Product Code. 15428539 Supplier Thermo Scientific Alfa Aesar Supplier No. J66960.MB
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Description

Possesses anti-tumor activity | CAS: 75747-14-7 | C31H43N3O8 | 585.698 g/mol

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

Solubility
Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 75747-14-7
Molecular Formula C31H43N3O8
Molecular Weight (g/mol) 585.698
MDL Number MFCD04973892
InChI Key AYUNIORJHRXIBJ-MKJFUHJFSA-N
Synonym 17-aag
PubChem CID 133688938
IUPAC Name [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Specifications

Melting Point 207°C to 209°C
Flash Point >110°C (230°F)
Quantity 25 mg
Sensitivity Light sensitive
Solubility Information Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/ml; Very poorly soluble in water
Formula Weight 585.69
Percent Purity 99%
Physical Form Solid
Chemical Name or Material 17-(Allylamino)-17-demethoxygeldanamycin

RUO – Research Use Only

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