CAS RN 2226521-65-7

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FM-381, MedChemExpress

MedChemExpress FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	428.49
Color	Yellow
Physical Form	Solid
Chemical Name or Material	FM-381
Grade	Research
SMILES	CN(C(/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)O1)=O)C
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.25%
CAS	2226521-65-7
Solubility Information	DMSO : 8.33 mg/mL (19.44 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₄N₆O₂
Formula Weight	428.49

CAS RN 2226521-65-7

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