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CAS RN 2206736-04-9

CAS RN 2206736-04-9

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MRTX-1257, MedChemExpress

MedChemExpress MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 565.71
Color Light Yellow
Physical Form Solid
Chemical Name or Material MRTX-1257
Grade Research
SMILES N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.03%
CAS 2206736-04-9
Solubility Information DMSO : 55 mg/mL (97.22 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage -20°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life -20°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula C33H39N7O2
Formula Weight 565.71