CAS RN 1332331-08-4

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Tocris Bioscience™ GSK 2194069

Potent human fatty acid synthase (hFASN) inhibitor

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Specifications

CAS	1332331-08-4
Chemical Name or Material	4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
Recommended Storage	Store at 4°C
Molecular Formula	C₂₅H₂₄N₄O₃
Formula Weight	Observed MW: 428.48
Assay Percent Range	>99%

GSK2194069, MedChemExpress

MedChemExpress GSK2194069 is a potent inhibitor of β-ketoyl reductase (KR) of fatty acid synthase (FAS), with an IC50 value of 7.7 nM. GSK2194069 shows specifically inhibitory effect on FAS expressing cancer cells, by acting potent efficacy on acetoacetyl-CoA, NADPH with IC50 or Ki values of 4.8 nM and 5.6 nM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	428.48
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	GSK2194069
Grade	Research
SMILES	O=C(N1C[C@H](CC2=NNC(N2C3=CC=C(C4=CC=C(OC=C5)C5=C4)C=C3)=O)CC1)C6CC6
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.67%
CAS	1332331-08-4
Solubility Information	DMSO : ≥ 100 mg/mL (233.38 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₄N₄O₃
Formula Weight	428.48

CAS RN 1332331-08-4

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Tocris Bioscience™ GSK 2194069 Greener Choice ProductThis product offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”Learn More About the Greener Choice Program

Tocris Bioscience™ GSK 2194069