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CAS RN 1256589-74-8

CAS RN 1256589-74-8

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1

CH5424802 (Alectinib) Hydrochloride, TRC

CAS: 1256589-74-8 Molecular Formula: C30 H34 N4 O2 . Cl H Molecular Weight (g/mol): 519.08 Synonym: 5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-, hydrochloride (1:1),Alectinib hydrochloride IUPAC Name: 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;hydrochloride SMILES: Cl.CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N5CCC(CC5)N6CCOCC6

CAS 1256589-74-8
Molecular Weight (g/mol) 519.08
SMILES Cl.CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N5CCC(CC5)N6CCOCC6
Synonym 5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-, hydrochloride (1:1),Alectinib hydrochloride
IUPAC Name 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;hydrochloride
Molecular Formula C30 H34 N4 O2 . Cl H
2

Alectinib Hydrochloride, MedChemExpress

MedChemExpress Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 519.08
Color Off-White
Physical Form Powder
Chemical Name or Material Alectinib Hydrochloride
Grade Research
SMILES [H]Cl.N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.06%
CAS 1256589-74-8
Solubility Information DMSO : 5 mg/mL (9.63 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (insoluble)
Synonym CH5424802 HydrochlorideRO5424802 HydrochlorideAF-802 Hydrochloride
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C30H35ClN4O2
Formula Weight 519.08