CAS RN 1223403-58-4

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Larotrectinib, MedChemExpress

MedChemExpress Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).

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Specifications

Molecular Weight (g/mol)	428.44
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Larotrectinib
Grade	Research
SMILES	O=C(N1C[C@@H](O)CC1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.92%
CAS	1223403-58-4
Solubility Information	DMSO : ≥ 4.6 mg/mL (10.74 mM)
Synonym	LOXO-101 ARRY-470
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₂F₂N₆O₂
Formula Weight	428.44

CAS RN 1223403-58-4

CAS RN 1223403-58-4

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