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CAS RN 118414-82-7

H3CSH3CCH3OHONClH3CCH3

CAS RN 118414-82-7

IUPAC Name: 3-[3-(butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
Synonyms: 3-[3-(butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
Molecular Weight (g/mol): 472.08
Molecular Formula: C27H34ClNO2S
InChi Key: VFMGWQLOCZBFCK-UHFFFAOYSA-N
SMILES: CCCCSC1=C(CC(C)(C)C(O)=O)N(CC2=CC=C(Cl)C=C2)C2=CC=C(C=C12)C(C)C
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Tocris Bioscience™ MK 886

Inhibitor of 5-lipoxygenase-activating protein (FLAP)

2

MK-886, TRC

CAS: 118414-82-7 Molecular Formula: C27H34ClNO2S Molecular Weight (g/mol): 472.08 Synonym: MK-886,L 663536 SMILES: CC(C)c1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc3ccc(Cl)cc3

CAS 118414-82-7
Molecular Weight (g/mol) 472.08
SMILES CC(C)c1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc3ccc(Cl)cc3
Synonym MK-886,L 663536
Molecular Formula C27H34ClNO2S
3

MK-886, MedChemExpress

MedChemExpress MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 472.08
Color White
Physical Form Solid
Chemical Name or Material MK-886
Grade Research
SMILES CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.11%
CAS 118414-82-7
Solubility Information DMSO : 75 mg/mL (158.87 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Synonym L 663536
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C27H34ClNO2S
Formula Weight 472.08