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Tocris Bioscience™ MK 886

Product Code. 18024302
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Quantity:
2 mg
Unit Size:
2mg
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Product Code. 18024302 Supplier Tocris Bioscience™ Supplier No. 1311/2

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Description

Inhibitor of 5-lipoxygenase-activating protein (FLAP)

MK 886 is a potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Also moderately potent PPARα antagonist (IC50 = 0.5-1 μM). Orally active in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid
CAS 118414-82-7
Quantity 2 mg
Target Lipoxygenase Inhibitors
Molecular Formula C27H34ClNO2S
Purity 98%
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