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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1 – 15 of 18 results
1

Thermo Scientific™ Pierce™ Sulfo-SANPAH, No-Weigh™ Format

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store at -20°C protected from light and moisture.
Cleavable By Thiols
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 492.4
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Nonselective
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Spacer Arm Length 18.2 Å
PEGylated No
2

Thermo Scientific™ Pierce™ DSP, No-Weigh™ Format

Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.

EDGE
Content And Storage Upon receipt store desiccated at 4°C.
Description DSP
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 404.42
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety NHS Ester
Spacer Arm Length 12.0 Å
PEGylated No
3

Thermo Scientific™ Pierce™ Premium Grade DSP (dithiobis(succinimidyl propionate))

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this popular amine-reactive, cleavable crosslinker.

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 404.42
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Formulation Dithiobis(succinimidylpropionate); powder solid
Reactive Moiety NHS Ester
Spacer Arm Length 12.0 Å
Product Line Pierce™
PEGylated No
4
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Thermo Scientific™ Pierce™ SMCC

No-Weigh™ Format

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 334.32
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability Yes
Format Standard, Single-use
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 8.3 Å
PEGylated No
5

Thermo Scientific™ PDPH (3-(2-pyridyldithio)propionyl hydrazide)

Crosslink sulfhydryls to periodate-treated glycoprotein sugars via cleavable disulfide bonds using this short crosslinker containing pyridyldithiol and hydrazide groups.

6

Thermo Scientific™ PEG12-SPDP (PEGylated, long-chain SPDP crosslinker)

Very long (54.1A) amine-to-sulfhydryl crosslinker; NHS-ester and pyridyldithiol groups at ends of 12-unit polyethylene glycol spacer arm; forms cleavable disulfide bonds; water-soluble.

7

Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.

8

Invitrogen™ Succinimidyl 3-(2-Pyridyldithio)Propionate (SPDP)

The succinimidyl ester chemically reacts with primary amines and after mild reduction of the dithiol, it can react form a disulfide with other thiols.

9

Thermo Scientific™ DTBP (Wang and Richard's Reagent)

Crosslink amines to amines with dithiobispropionimidate; composed of imidoester groups at either end of a reducible (cleavable) disulfide-containing spacer arm.

10

Thermo Scientific™ LC-SPDP (succinimidyl 6-(3(2-pyridyldithio)propionamido)hexanoate)

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups at ends of 10-atom (15.7A) spacer arm.

11

Thermo Scientific™ Sulfo-LC-SPDP (sulfosuccinimidyl 6-(3'-(2-pyridyldithio)propionamido)hexanoate)

Crosslink amines to sulfhydryls with this water-soluble sulfo-NHS-ester and pyridyldithiol groups on 10-atom spacer arms to form cleavable disulfide bonds with cysteines.

12

Thermo Scientific™ Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) (sulfosuccinimidyl 2-((4,4'-azipentanamido)ethyl)-1,3'-dithiopropionate)

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

13

Thermo Scientific™ SMPT (4-succinimidyloxycarbonyl-alpha-methyl-α(2-pyridyldithio)toluene)

Crosslink amines to sulfhydryls with this crosslinker containing NHS-ester and pyridyldithiol groups at the ends of an aromatic, 6-atom (11.2A) spacer arm.

14

Thermo Scientific™ SDAD (NHS-SS-Diazirine) (succinimidyl 2-((4,4'-azipentanamido)ethyl)-1,3'-dithiopropionate)

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

15

Thermo Scientific™ DTME (dithiobismaleimidoethane)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, cleavable crosslinker composed of maleimide groups and 11-atom (13.3A) disulfide spacer arm.