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Pyrazines

Aromatic organic heterocyclic compounds that consist of a six-membered ring with four carbon atoms and two nitrogen atoms at opposite positions of the ring, making this ring symmetrical.
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1

2-Pyrazinecarboxylic acid, 99%

CAS: 98-97-5 Molecular Formula: C5H4N2O2 Molecular Weight (g/mol): 124.1 MDL Number: MFCD00006130 InChI Key: NIPZZXUFJPQHNH-UHFFFAOYSA-N Synonym: 2-pyrazinecarboxylic acid,pyrazinoic acid,pyrazinecarboxylic acid,pyrazinic acid,2-carboxypyrazine,paradiazinecarboxylic acid,pyrazinemonocarboxylic acid,2-pyrazinoic acid,2-pyrazine carboxylic acid,piazinecarboxylic acid PubChem CID: 1047 ChEBI: CHEBI:71311 IUPAC Name: pyrazine-2-carboxylic acid SMILES: C1=CN=C(C=N1)C(=O)O

PubChem CID 1047
CAS 98-97-5
Molecular Weight (g/mol) 124.1
ChEBI CHEBI:71311
MDL Number MFCD00006130
SMILES C1=CN=C(C=N1)C(=O)O
Synonym 2-pyrazinecarboxylic acid,pyrazinoic acid,pyrazinecarboxylic acid,pyrazinic acid,2-carboxypyrazine,paradiazinecarboxylic acid,pyrazinemonocarboxylic acid,2-pyrazinoic acid,2-pyrazine carboxylic acid,piazinecarboxylic acid
IUPAC Name pyrazine-2-carboxylic acid
InChI Key NIPZZXUFJPQHNH-UHFFFAOYSA-N
Molecular Formula C5H4N2O2
3

Gilteritinib, MedChemExpress

MedChemExpress Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 552.71
Color Light Yellow
Physical Form Solid
Chemical Name or Material Gilteritinib
Grade Research
SMILES NC(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 97.77%
CAS 1254053-43-4
Solubility Information Ethanol : 100 mg/mL (180.93 mM; ultrasonic and adjust pH to 2 with HCl) ∣DMSO : 2 mg/mL (3.62 mM; Need ultrasonic)
Synonym ASP2215
Purity Grade Notes Research
Recommended Storage 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula C29H44N8O3
Formula Weight 552.71
4

Bortezomib, MedChemExpress

MedChemExpress Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 384.24
Color White
Physical Form Solid
Chemical Name or Material Bortezomib
Grade Research
SMILES OB(O)[C@H](CC(C)C)NC([C@@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 179324-69-7
Solubility Information Ethanol : 66.67 mg/mL (173.51 mM; ultrasonic and warming and heat to 60°C) ∣DMSO : 50 mg/mL (130.13 mM; Need ultrasonic)
Health Hazard 1 H300∣H315∣H319∣H361∣H372∣H411
Synonym PS-341 LDP-341 NSC 681239
Purity Grade Notes Research
Recommended Storage 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Shelf Life 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molecular Formula C19H25BN4O4
Formula Weight 384.24