Indoles and derivatives

Aromatic bicyclic organic compounds that consists of a benzene ring fused to a pyrrole ring with formula: C₈H₇N.

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PD146176, MedChemExpress

MedChemExpress PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

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NecroX-5, MedChemExpress

MedChemExpress NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	645.81
Color	Light Brown to Black
Physical Form	Solid
Chemical Name or Material	NecroX-5
Grade	Research
SMILES	O=S1(CCN(CC2=CC3=C(NC(C4=CC=CC=C4)=C3)C(NCC5CCOCC5)=C2)CC1)=O.CS(=O)(O)=O.CS(=O)(O)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.52%
CAS	1383718-29-3
Solubility Information	DMSO : 170 mg/mL (263.24 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life	4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula	C₂₇H₃₉N₃O₉S₃
Formula Weight	645.81

Indoles and derivatives

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