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Furofurans

Organic bicyclic compounds that consist of two fused furan rings; furan rings consist of a five-membered ring with four carbon atoms, one oxygen atom, and two double bonds.

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1

Eribulin mesylate, MedChemExpress

MedChemExpress Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin mesylate inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

ENCOMPASS_PREFERRED
2

AZD5904, MedChemExpress

MedChemExpress AZD5904 is a selective and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 252.29
Color Yellow
Physical Form Solid
Chemical Name or Material AZD5904
Grade Research
SMILES O=C1NC(N(C[C@@H]2OCCC2)C3=C1N=CN3)=S
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.0%
CAS 618913-30-7
Solubility Information DMSO : 22.73 mg/mL (90.09 mM; Need ultrasonic)
Health Hazard 1 H361
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C10H12N4O2S
Formula Weight 252.29
3

Saridegib, MedChemExpress

MedChemExpress Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 504.77
Color White
Physical Form Solid
Chemical Name or Material Saridegib
Grade Research
SMILES CC1=C(C[C@@]2([H])[C@@]3([H])CC[C@@]4([H])[C@]2(C)CC[C@@H](NS(C)(=O)=O)C4)[C@@]3([H])CC[C@@]([C@@H]5C)(C1)O[C@@]6([H])[C@@]5([H])NC[C@@H](C)C6
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.0%
CAS 1037210-93-7
Synonym IPI-926 Patidegib
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C29H48N2O3S
Formula Weight 504.77
4

Fursultiamine, MedChemExpress

MedChemExpress Fursultiamine is a vitamin B1 derivative, has anti-nociceptive and antineoplastic activity. Fursultiamine can be used for vitamin B1 deficiency, osteoarthritis (OA) and cancer research.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 398.54
Color White
Physical Form Solid
Chemical Name or Material Fursultiamine
Grade Research
SMILES O=CN(CC1=CN=C(C)N=C1N)/C(C)=C(SSCC2OCCC2)\CCO
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.86%
CAS 804-30-8
Solubility Information DMSO : 106.7 mg/mL (267.73 mM; Need ultrasonic and warming)
Health Hazard 1 H302∣H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H26N4O3S2
Formula Weight 398.54
5

Spironolactone, MedChemExpress

MedChemExpress Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 416.57
Color White
Physical Form Solid
Chemical Name or Material Spironolactone
Grade Research
SMILES C[C@@]12[C@](OC3=O)(CC3)CC[C@@]1([H])[C@@]([C@@H](CC4=CC5=O)SC(C)=O)([H])[C@]([C@]4(CC5)C)([H])CC2
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.58%
CAS 52-01-7
Solubility Information DMSO : ≥ 50 mg/mL (120.03 mM) ∣H2O : 0.1 mg/mL (0.24 mM; Need ultrasonic)
Health Hazard 1 H360
Synonym SC9420
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H32O4S
Formula Weight 416.57