ZSCAN4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520901

Product Code. 12829042

Description

A suggested positive control is mouse lung tissue lysate. PA5-20901 can be used with blocking peptide PEP-1015.

Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.

Specifications

• Antigen: ZSCAN4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZSCAN4
• Gene Alias: BQ559217; C330039H09Rik; RGD1563625; zinc finger and SCAN domain containing 4; zinc finger and SCAN domain containing 4A; zinc finger and SCAN domain containing 4F; zinc finger and SCAN domain containing protein 4F; Zinc finger and SCAN domain-containing protein 4; zinc finger protein 494; ZNF494; ZSCAN4; Zscan4a; Zscan4f
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 201516, 434555, 503124, 665902
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q3URS2, Q8NAM6
• Gene Symbols: ZSCAN4, Zscan4a, Zscan4f
• Immunogen: An 18 amino acid peptide near the carboxy terminus of human ZSCAN4.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG