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STEMCELL Technologies Zoledronic Acid (Hydrate)

Product Code. 17180242
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50 mg
Unit Size:
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Product Code. 17180242 Supplier STEMCELL Technologies Supplier No. 73572

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Description

Inhibitor of bone resorption; Inhibits farnesyl diphosphate (FPP) synthase

  • Zoledronic acid is a nitrogen-containing bisphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC50 = 5 nM), thereby preventing protein prenylation and osteoclast-mediated bone resorption (Dunford et al.) In addition, it has a high affinity for hydroxyapatite (Ki = 3.5 μM) which allows it to bind directly to mineralized bone (Nancollas et al.) This product is supplied as the hydrate form of the molecule
  • Inhibits proliferation, angiogenesis, and adhesion to bone, in several cancer cell lines (Li & Davis; Zekri et al.)
  • Inhibits breast and prostate carcinoma cell invasion in vitro (Boissier et al.; Li & Davis)
  • Induces apoptosis of osteoclastoma cells in vitro (Benford et al.)

Specifications

CAS 165800-06-6
Synonym Zoledronate
Quantity 50 mg
Molecular Formula C5H10N2O7P2 · H2O
Purity ≥95%
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