Invitrogen™ ZNRF1 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA537982

Product Code. 15564911

Description

This antibody is predicted to react with human, rat, dog, pig and cow based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Specifications

• Antigen: ZNRF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNRF1
• Gene Alias: B830022L21Rik; E3 ubiquitin-protein ligase ZNRF1; MGC101991; nerve injury gene 283; nerve injury-induced gene 283 protein; Nin283; peripheral nerve injury protein nin283; ring finger protein 42; RING-type E3 ubiquitin transferase ZNRF1; Rnf42; zgc:77896; zinc and ring finger 1; zinc and ring finger 1, E3 ubiquitin protein ligase; zinc and ring finger protein 1; zinc ring finger protein 1; zinc/RING finger protein 1; ZNRF1; Zrfp1
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 170737, 84937
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8ND25, Q91V17
• Gene Symbols: ZNRF1
• Immunogen: Peptide with sequence C-SDSTYAHGNGYQET, from the internal region of mouse Znrf1 (aa 93-107).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG