Invitrogen™ ZNRF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA555632

Product Code. 15753551

Description

Immunogen sequence: ASDSTYAHGN GYQETGGGHH RDGMLYLGSR ASLADALPLP IAPRWFSSHS GFKCPICSKS VASDEMEMHF I Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Specifications

• Antigen: ZNRF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNRF1
• Gene Alias: B830022L21Rik; E3 ubiquitin-protein ligase ZNRF1; MGC101991; nerve injury gene 283; nerve injury-induced gene 283 protein; Nin283; peripheral nerve injury protein nin283; ring finger protein 42; RING-type E3 ubiquitin transferase ZNRF1; Rnf42; zgc:77896; zinc and ring finger 1; zinc and ring finger 1, E3 ubiquitin protein ligase; zinc and ring finger protein 1; zinc ring finger protein 1; zinc/RING finger protein 1; ZNRF1; Zrfp1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84937
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8ND25
• Gene Symbols: ZNRF1
• Immunogen: Recombinant protein corresponding to Human ZNRF1. Recombinant protein control fragment (Product #RP-93636).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG