Invitrogen™ ZNF598 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA531409

Product Code. 13445927

Description

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Zebrafish (85%), Xenopus laevis (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.

Specifications

• Antigen: ZNF598
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF598
• Gene Alias: BC023040; C6orf149; E3 ubiquitin-protein ligase ZNF598; FLJ00086; ISD11; Ntrap; Zfp598; Zinc finger protein 598; ZNF598
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 213753, 90850
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.29 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q80YR4, Q86UK7
• Gene Symbols: Zfp598, ZNF598
• Immunogen: Recombinant protein encompassing a sequence within the center region of human ZNF598. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG