Invitrogen™ ZNF521 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA554898

Product Code. 15702831

Description

Immunogen sequence: VTVGYTSVSS TTPDSNLSVD SSTMVEAAPP IPKSRGRKRA AQQTPDMTGP SSKQAKVTYS CIYCNKQLFS SLAVLQIHLK TMH Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.

Specifications

• Antigen: ZNF521
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF521
• Gene Alias: B930086A16Rik; early hematopoietic zinc finger protein; Ecotropic viral integration site 3 protein; EHZF; Evi3; LIP3; LYST-interacting protein 3; Zfp521; Zinc finger protein 521; Znf521
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25925
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: Lot-Specific
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96K83
• Gene Symbols: ZNF521
• Immunogen: Recombinant protein corresponding to Human ZNF521. Recombinant protein control fragment (Product #RP-93654).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG