Invitrogen™ ZNF451 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA569000

Product Code. 15837413

Description

This target displays homology in the following species: Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 87%; Rat: 100%.

E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). [UniProt].

Specifications

• Antigen: ZNF451
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF451
• Gene Alias: 4930515K21Rik; 4933435G09Rik; AI596398; Coactivator for steroid receptors; COASTER; dJ417I1.1; E3 SUMO-protein ligase ZNF451; E3 SUMO-protein ligase ZNF451; zinc finger protein 451; E3 SUMO-protein transferase ZNF451; KIAA0576; Kiaa0576-hp; KIAA1702; mKIAA1702; Zfp451; Zinc finger protein 451; Zinc finger protein 451-like protein; Znf451
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26036
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9Y4E5
• Gene Symbols: ZNF451
• Immunogen: synthetic peptide directed towards the C terminal region of human ZNF451.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG