Invitrogen™ ZNF350 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA581951

Product Code. 16398914

Description

Immunogen sequence: FKLEQGEQLW TIEDGIHSGA CSDIWKVDHV LERLQSESLV NRRKPCHEHD AFENIVHCSK SQFLLGQNHD IFDLRGKSLK SNLTLVNQSK GYEIKNSVEF TGNGDSFLHA NHERLHTAIK FPASQ Highest antigen sequence indentity to the following orthologs: Mouse - 25%, Rat - 25%.

ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.

Specifications

• Antigen: ZNF350
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF350
• Gene Alias: KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; zinc finger protein 350; Zinc finger protein ZBRK1; zinc-finger protein ZBRK1; ZNF350
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 59348
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9GZX5
• Gene Symbols: ZNF350
• Immunogen: Recombinant protein corresponding to Human ZNF350. Recombinant protein control fragment (Product #RP-99731).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG