Invitrogen™ ZMYND10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5112790

Product Code. 17110654

Description

ZMYND10 Polyclonal Antibody for Western Blot, IHC (P), ELISA

The ZMYND10 gene encodes a protein that contains a MYND-type zinc finger domain, playing a crucial role in the assembly and function of cilia. Specifically, ZMYND10 is essential for the proper axonemal assembly of both inner and outer dynein arms, which are critical components of motile cilia. Mutations in ZMYND10 are associated with primary ciliary dyskinesia (PCD), a genetic disorder characterized by defective ciliary motility leading to recurrent respiratory infections and male infertility. In model organisms like mice and Drosophila, ZMYND10 expression is restricted to tissues and cells with motile cilia, such as chordotonal sensory neurons and sperm cells. Additionally, ZMYND10 has been identified as an epigenetically regulated tumor suppressor in various cancers, with its downregulation affecting processes like cell proliferation and tumor progression. The gene's dual role in ciliary function and tumorigenesis underlines its importance in both normal cellular physiology and disease pathology.

Specifications

• Antigen: ZMYND10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Zmynd10
• Gene Alias: Blu; CILD22; FLU; LUCA12.4; Protein BLu; zinc finger MYND domain-containing protein 10; zinc finger MYND-type containing 10; zinc finger, MYND domain containing 10; zinc finger, MYND domain-containing 10; zinc finger, MYND-type containing 10; Zmynd10
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114602, 51364
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.78 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O75800, Q99ML0
• Gene Symbols: Zmynd10
• Immunogen: Recombinant Human Zinc finger MYND domain-containing protein 10 protein (201-440AA).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG