Invitrogen™ ZIP12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA590883

Product Code. 16568031

Description

Immunogen sequence: MCFRTKLSVS WVPLFLLLSR VFSTETDKPS AQDSRSRGSS GQPADLLQVL SAGDHPPHNH SRSLIKTLLE KTGCPRRRNG MQGDCNLCFE PDALLLIAGG; Positive Samples: 293T, mouse brain, mouse eye, mouse lung, rat brain.

The zinc transporter ZIP12, also known as SLC39A12, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP12 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Increased levels of ZIP12 have been observed during acute inflammation in the airway and asthma, suggesting that it may be promote increased zinc uptake, as this can reduce inflammation. The zinc content in brains in individuals with schizophrenia is lower than in individuals with other cerebral diseases, and mutations in ZIP12 have been observed in a small group of schizophrenic patients, suggesting that ZIP12 may play a role in this disease.

Specifications

• Antigen: ZIP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC39A12
• Gene Alias: AW046938; bA570F3.1; Gm731; LIV-1 subfamily of ZIP zinc transporter 8; LZT-Hs8; Slc39a12; solute carrier family 39 (metal ion transporter), member 12; solute carrier family 39 (zinc transporter), member 12; solute carrier family 39 member 12; Zinc transporter ZIP12; Zip12; ZIP-12; Zrt- and Irt-like protein 12
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 221074, 277468, 291328
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.07 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q504Y0, Q5FWH7
• Gene Symbols: SLC39A12
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC39A12 (NP_0011386671).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG