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Invitrogen™ ZIP1 Polyclonal Antibody

Product Code. 12849212
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Quantity:
100 μg
Unit Size:
100µg
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12849212 100 μg 100µg
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Product Code. 12849212 Supplier Invitrogen™ Supplier No. PA521066

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse kidney tissue lysate. PA5-21066 can be used with blocking peptide PEP-1180.

ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappa-B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZIP1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Slc39a1
Gene Accession No. Q9NY26, Q9QZ03
Gene Alias CGI-08; CGI-71; IRT1; mZIP1; SLC39A1; solute carrier family 39 (zinc transporter), member 1; solute carrier family 39 (zinc transporter), member 3; solute carrier family 39 member 1; Zinc transporter ZIP1; Zinc-iron-regulated transporter-like; Zip1; ZIP-1; ZIRTL; Zrt- and Irt-like protein 1; Zrt/Irt-like protein 1
Gene Symbols Slc39a1
Host Species Rabbit
Immunogen A 16 amino acid peptide near the amino terminus of human ZIP1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27173, 30791
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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