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Invitrogen™ ZIP1 Polyclonal Antibody
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Product Code. 17258693 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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17258693 100 μL 100µL
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Product Code. 17258693 Supplier Invitrogen™ Supplier No. PA5115913

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SLC39A1.

ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappa-B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZIP1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene Slc39a1
Gene Accession No. Q9NY26, Q9QZ03
Gene Alias CGI-08; CGI-71; IRT1; mZIP1; SLC39A1; solute carrier family 39 (zinc transporter), member 1; solute carrier family 39 (zinc transporter), member 3; solute carrier family 39 member 1; Zinc transporter ZIP1; Zinc-iron-regulated transporter-like; Zip1; ZIP-1; ZIRTL; Zrt- and Irt-like protein 1; Zrt/Irt-like protein 1
Gene Symbols Slc39a1
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLC39A1(Accession Q9NY26), corresponding to amino acid residues L111-D161.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27173, 30791, 361986
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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