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Description
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission
Specifications
Specifications
| Antigen | ZFYVE19 |
| Applications | Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.65 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | ZFYVE19 |
| Gene Accession No. | Q96K21 |
| Gene Alias | MPFYVE, ZFYVE19 |
| Gene Symbols | ZFYVE19 |
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