Invitrogen™ ZFP36 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5107314

Product Code. 17197113

Description

Sequence homology: Cow: 86%; Dog: 86%; Guinea Pig: 86%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 86%; Sheep: 86%.

ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.

Specifications

• Antigen: ZFP36
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Zfp36
• Gene Alias: G0/G1 switch regulatory protein 24; G0S24; GOS24; growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; Nup475; RNF162A; Tax interacting protein; TIS11; TIS11A; TIS11D; TISII; TNF alpha inhibitor; TPA-induced sequence 11; Tristetraprolin; tristetraprolin; LOW QUALITY PROTEIN: mRNA decay activator protein ZFP36; tristetraproline; TTP; Zfp36; zfp-36; ZFP36 ring finger protein; zinc finger protein 36; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog; zinc finger protein, C3H type, 36 homolog
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7538
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P26651
• Gene Symbols: Zfp36
• Immunogen: Synthetic peptide directed towards the N terminal region of human ZFP36.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG