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ZBP1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5143927
This item is not returnable.
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Description
Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
Specifications
| ZBP1 | |
| Polyclonal | |
| Unconjugated | |
| ZBP1 | |
| 2010010H03Rik; C20orf183; Dai; Dlm1; DLM-1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; mZaDLM; RP4-718J7.1; Tumor stroma and activated macrophage protein DLM-1; Zbp1; Z-DNA binding protein 1; Z-DNA-binding protein 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 81030 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| IgG |
| ELISA, Flow Cytometry, Immunocytochemistry, Western Blot | |
| 500 μg/mL | |
| PBS with 4MG trehalose and no preservative | |
| Q9H171 | |
| ZBP1 | |
| E.coli-derived human DAI/ZBP1 recombinant protein (Position: A2-E421). | |
| 100 μg | |
| Primary | |
| Human | |
| Lyophilized |