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Tocris Bioscience™ YNT 185
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Product Code. 18789956
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10 mg
Unit Size:
10mg
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Product Code. 18789956 Supplier Tocris Bioscience™ Supplier No. 6739/10

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Description

Potent and selective OX2 agonist

YNT 185 is a potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
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Specifications

Chemical Name or Material 3-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4-methoxy-N,N-dimethyl-[1,1-biphenyl]-3-carboxamide dihydrochloride
CAS 1804978-82-2
Quantity 10 mg
Target OX2 Receptor Agonists
Molecular Formula C33H37N5O5S0.2 HCl
Formula Weight 2778
Purity 98%
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