Invitrogen™ YAP1 Monoclonal Antibody (GT256)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA527808

Product Code. 16352314

Description

Positive Control: HeLa, HepG2 Predicted Reactivity: Rat (96%), Zebrafish (87%), Xenopus laevis (81%), Chicken (84%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.

Specifications

• Antigen: YAP1
• Classification: Monoclonal
• Concentration: 1.68 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P46937, P46938
• Gene Symbols: YAP1
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human YAP1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: GT256
• Conjugate: Unconjugated
• Gene: YAP1
• Gene Alias: 65 kDa Yes-associated protein; AI325207; cb194; CH211-181P1.5-001; COB1; Protein yorkie homolog; sb:cb194; si:ch211-181p1.5; si:dkey-3b8.3; transcriptional coactivator YAP1; wu:fc18c04; yap; Yap1; YAP2; Yap65; Yes associated protein 1; Yes1 associated transcriptional regulator; yes-associated protein 1; yes-associated protein 2; yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; Yki; Yorkie; yorkie homolog; zgc:158380; zYAP
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 10413, 22601
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid