Invitrogen™ XRCC4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582264

Product Code. 16389224

Description

Immunogen sequence: KCVSAKEALE TDLYKRFILV LNEKKTKIRS LHNKLLNAAQ EREKDIKQEG ETAICSEMTA DRDPVYDEST DEESENQTDL SGLASAAVSK DDSIISSLDV TDIAPSRKRR QRMQRNLGTE PKMAPQENQL QEK Highest antigen sequence indentity to the following orthologs: Mouse - 67%, Rat - 63%.

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.

Specifications

• Antigen: XRCC4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: XRCC4
• Gene Alias: 2310057B22Rik; AW413319; AW545101; DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7518
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q13426
• Gene Symbols: XRCC4
• Immunogen: Recombinant protein corresponding to Human XRCC4. Recombinant protein control fragment (Product #RP-89487).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG