Invitrogen™ XPNPEP3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA521665

Product Code. 13289048

Description

Recommended positive controls: 293T, A431, H1299, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (92%), Rat (90%), Chimpanzee (99%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

XPNPEP3, also known as X-Prolyl Aminopeptidase 3, is a gene located on chromosome 22q that encodes an enzyme involved in the processing of mitochondrial matrix proteins. The enzyme is classified under the M24B subfamily of metallopeptidases, which specifically remove the N-terminal amino acid from oligopeptides where the penultimate residue is proline. XPNPEP3 is implicated in conditions such as cystic kidney disease and participates in TNF-TNFR2 cellular signaling pathways. Its yeast and plant homologs, like Icp55, perform similar functions by stabilizing proteins after import into the mitochondrial matrix. Mutations in XPNPEP3 are associated with defects in ciliary structure and function, contributing to the phenotypic spectrum seen in nephronophthisis-related ciliopathies (NPHP-RCs). The crystal structure of XPNPEP3 has been resolved at 1.65 A resolution, revealing its interaction with inhibitors such as apstatin. Furthermore, XPNPEP3 is identified as a transcriptional target of the canonical Wnt/beta-catenin signaling pathway, with elevated transcript levels observed in tumors exhibiting activated Wnt signaling.

Specifications

• Antigen: XPNPEP3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: XPNPEP3
• Gene Alias: Aminopeptidase P3; APP3; E430012M05Rik; ICP55; Intermediate Cleaving Peptidase 55; LOW QUALITY PROTEIN: xaa-Pro aminopeptidase 3; NPHPL1; probable Xaa-Pro aminopeptidase 3; putative Xaa-Pro aminopeptidase 3; Xaa-Pro aminopeptidase 3; xaa-Pro aminopeptidase 3; probable Xaa-Pro aminopeptidase 3; XPNPEP3; X-Pro aminopeptidase 3; X-prolyl aminopeptidase (aminopeptidase P) 3, putative; X-prolyl aminopeptidase 3; X-prolyl aminopeptidase 3, mitochondrial; zgc:76905; zgc:76905 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 63929
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9NQH7
• Gene Symbols: XPNPEP3
• Immunogen: Recombinant protein encompassing a sequence within the center region of human XPNPEP3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG