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Invitrogen™ XPG Monoclonal Antibody (8H7)

Product Code. 11569452
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
11569452 100 μg 100µg
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Product Code. 11569452 Supplier Invitrogen™ Supplier No. MA126186

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Description

Mouse Monoclonal Antibody

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPG
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 8H7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene ERCC5
Gene Accession No. P28715
Gene Alias COFS 3; COFS3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; DNA repair protein complementing XP-G cells homolog; ERCC 5; ERCC excision repair 5, endonuclease; ERCC5; ERCC5-201; ERCM 2; ERCM2; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; OTTHUMP00000064902; RP11-484I6.5; UVDR; Xe; xeroderma pigmentosum; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; XPG; XPGC; XPG-complementing protein
Gene Symbols ERCC5
Host Species Mouse
Immunogen Recombinant human XPG (Xeroderma Pigmentosum type G) protein produced in Baculovirus.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2073
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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