Invitrogen™ XPC Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA3956

Product Code. 11528871

Description

PA3-956 detects XPC in human and mouse cells. PA3-956 has been successfully used in Western blotting and ICC/IF procedures. By Western blot it detects a ~125 kDa protein representing XPC. The PA3-956 immunogen is two synthetic peptides, individually conjugated to the C-Terminus and N-Terminus respectively of human XPC.

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Specifications

• Antigen: XPC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: XPC
• Gene Alias: DNA repair protein complementing XP-C cells; DNA repair protein complementing XP-C cells homolog; mutant xeroderma pigmentosum group C; NER; p125; RAD4; Xeroderma pigmentosum group C-complementing protein; Xeroderma pigmentosum group C-complementing protein homolog; xeroderma pigmentosum, complementation group C; XP3; XPC; XPC complex subunit, DNA damage recognition and repair factor; XPCC
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: Whole Serum with 0.05% sodium azide
• Gene Accession No.: P51612, Q01831
• Gene Symbols: XPC
• Immunogen: Two synthetic peptides, individually conjugated to the C-Terminus and N-Terminus respectively of human XPC.
• Regulatory Status: RUO
• Gene ID (Entrez): 22591, 7508
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid