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Tocris Bioscience™ XMD 8-92

Product Code. 18084252
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Product Code. 18084252 Supplier Tocris Bioscience™ Supplier No. 4132/10

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ERK5/BMK1 inhibitor; also BRD4 inhibitor

ERK5 (BMK1) and BRD4 inhibitor (Kd values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1234480-50-2
Molecular Formula C26H30N6O3

Specifications

Quantity 10 mg
Formula Weight 474.55
Purity >98%
Molecular Weight (g/mol) 474.565
Chemical Name or Material XMD 8-92
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