STEMCELL Technologies XAV939

Product Code. 17180102

Brand: STEMCELL Technologies 72674

Descrizione

WNT pathway inhibitor; Inhibits TNKS1 and TNKS2

• XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 (IC₅₀ = 11 and 4 nM, respectively) (Huang et al.) By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells (Huang et al.), thereby inhibiting WNT pathway downstream actions
• Induces cardiomyogenesis in mesoderm progenitor cells derived from mouse embryonic stem cells (Wang et al.)
• In combination with the SMAD inhibitors LDN193189 and SB431542, promotes induction of forebrain fates in human pluripotent stem cell lines (Maroof et al.)
• Inhibits colony formation of APC-deficient, β-catenin-dependent DLD-1 colorectal cancer cells (Huang et al.)

Specifica

• CAS: 284028-89-3
• Quantity: 10 mg
• Molecular Formula: C₁₄H₁₁F₃N₂OS
• Purity: ≥98%