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  5. STEMCELL Technologies XAV939

STEMCELL Technologies XAV939

Product Code. 17170102
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Quantity:
1 mg
10 mg
Unit Size:
10mg
1mg
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Product Code. 17170102

Brand: STEMCELL Technologies 72672

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This item is not returnable. View return policy

Description

WNT pathway inhibitor; Inhibits TNKS1 and TNKS2

  • XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 (IC50 = 11 and 4 nM, respectively) (Huang et al.) By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells (Huang et al.), thereby inhibiting WNT pathway downstream actions
  • Induces cardiomyogenesis in mesoderm progenitor cells derived from mouse embryonic stem cells (Wang et al.)
  • In combination with the SMAD inhibitors LDN193189 and SB431542, promotes induction of forebrain fates in human pluripotent stem cell lines (Maroof et al.)
  • Inhibits colony formation of APC-deficient, β-catenin-dependent DLD-1 colorectal cancer cells (Huang et al.)

Specifications

CAS 284028-89-3
Quantity 1 mg
Molecular Formula C14H11F3N2OS
Purity ≥98%
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