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  7. XAV 939, Tocris Bioscience™

XAV 939, Tocris Bioscience™

Catalog Number 18065872
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
284028-89-3
C14H11F3N2OS
312.31
KLGQSVMIPOVQAX-UHFFFAOYSA-N
3,5,7,8-tetrahydro-2-4-trifluoromethyl phenyl-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiino 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydrothiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydro-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-3h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one
2726824
CHEBI:62878
2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
This item is not returnable. View return policy
284028-89-3
C14H11F3N2OS
312.31
KLGQSVMIPOVQAX-UHFFFAOYSA-N
3,5,7,8-tetrahydro-2-4-trifluoromethyl phenyl-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiino 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydrothiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydro-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-3h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one
2726824
CHEBI:62878
2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F

Description

Potent tankyrase inhibitor

XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols.

XAV 939 synthesized to cGMP guidelines also available.

For more information about how XAV 939 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs

Quantity 10 mg
Formula Weight 312.31
Percent Purity >98%
Chemical Name or Material XAV 939
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