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XAV-939, MedChemExpress

Product Code. 16446646
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Product Code. 16446646

Brand: Medchem Express HY15147

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Description

MedChemExpress XAV-939 is a potent tankyrase inhibitor that targets Wnt/β-catenin signaling. XAV-939 stabilizes axin by inhibiting tankyrase 1 and tankyrase 2 (IC50s of 5 and 2 nM, respectively), thereby stimulating β-catenin degradation. XAV939 binds tightly to the catalytic (PARP) domains of TNKS1 and TNKS2 (Kds of 99 and 93 nM, respectively).

XAV-939 is a potent tankyrase inhibitor that targets Wnt/β-catenin signaling. XAV-939 stabilizes axin by inhibiting tankyrase 1 and tankyrase 2 (IC50s of 5 and 2 nM, respectively), thereby stimulating β-catenin degradation. XAV939 binds tightly to the catalytic (PARP) domains of TNKS1 and TNKS2 (Kds of 99 and 93 nM, respectively).

Specifications

Chemical Name or Material XAV-939
Physical Form Solid
CAS 284028-89-3
Color Off-White
Quantity 100 mg
Purity Grade Notes Research
Molecular Formula C14H11F3N2OS
For Use With (Application) Cancer-programmed cell death
Solubility Information DMSO : 25 mg/mL (80.05 mM; ultrasonic and warming and heat to 60°C) ∣H2O : < 0.1 mg/mL (insoluble)
SMILES O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
Molecular Weight (g/mol) 312.31
Formula Weight 312.31
Percent Purity 95.0%
Grade Research
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Research purposes only

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