Invitrogen™ XAF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA141099

Product Code. 11518081

Description

Suggested positive control: antigen standard for XAF1 (transient overexpression lysate), human liver tissue or protein. Immunogen sequence: NQTSTMEKDV RPKTRSIN & QLDLEKERY YKFKRFHF.

The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.

Specifications

• Antigen: XAF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: XAF1
• Gene Alias: BIRC4 binding protein; BIRC4-binding protein; Birc4bp; F-box protein 39; Fbox39; HSXIAPAF1; novel TRAF-type zinc finger protein; XAF1; XIAP associated factor 1; XIAP associated factor-1; Xiapaf1; XIAP-associated factor 1
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 327959, 54739
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: Q5NBU8, Q6GPH4
• Gene Symbols: XAF1
• Immunogen: Amino acids 201-218 and 301-317 of human XAF1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG